Van Wouwe J P, Hoogenkamp S, Van den Hamer C J
Department of Radiochemistry, Delft University of Technology, The Netherlands.
Biol Trace Elem Res. 1991 Jun;29(3):175-80. doi: 10.1007/BF03032675.
In fetus with a mean gestational age of 18 weeks (range 15-25, n = 14), zinc and copper concentrations in liver, femur, rib, and skeletal muscle were measured. Zinc and copper concentrations are highest in liver. A trend of decreasing liver zinc concentrations during gestational age is suggested. Zinc concentrations are significantly correlated with copper concentrations in liver and in femur, suggesting steady growth in both organs. Femur zinc values rank ca. 30% of those in liver, femur copper, ca. 2%. Zinc or copper concentrations in rib are of the same levels as in skeletal muscle. Their concentration for zinc ranks ca. 20%, for copper, ca. 5% of the values in liver. All zinc and copper values are lower than reported in third trimester fetal organs. Calculated zinc/copper molar ratios are distinctive for the various organs: in liver, 6 +/- 1, in femur, 73 +/- 8, and in soft tissues, 26 +/- 3. Calculated ratios from published values obtained from the third trimester of pregnancy show that the ratios in liver and skeletal muscle maintain these levels. The zinc/copper molar ratio can serve as an internal reference in zinc and/or copper measurements.
在平均孕龄为18周（范围15 - 25周，n = 14）的胎儿中，测量了肝脏、股骨、肋骨和骨骼肌中的锌和铜浓度。锌和铜浓度在肝脏中最高。提示孕龄期间肝脏锌浓度有下降趋势。锌浓度与肝脏和股骨中的铜浓度显著相关，表明这两个器官均稳定生长。股骨锌值约为肝脏锌值的30%，股骨铜值约为肝脏铜值的2%。肋骨中的锌或铜浓度与骨骼肌中的水平相同。其锌浓度约为肝脏锌值的20%，铜浓度约为肝脏铜值的5%。所有锌和铜值均低于孕晚期胎儿器官中报道的值。计算得出的锌/铜摩尔比在不同器官中有所不同：肝脏中为6±1，股骨中为73±8，软组织中为26±3。根据妊娠晚期获得的已发表值计算得出的比率表明，肝脏和骨骼肌中的比率维持这些水平。锌/铜摩尔比可作为锌和/或铜测量中的内部参考。
