Shah Chirag A
Community Welfare Foundation, India.
Indian J Pediatr. 2007 Jan;74(1):55-60. doi: 10.1007/s12098-007-0028-8.
It has been proven that HAART is effective in suppressing human immunodeficiency virus (HIV) replication, decreasing morbidity and mortality associated with HIV and improving quality of life in adults as well as children infected with HIV. However, drugs don't work in patients who don't take them and in the management of HIV infection it is now well established that optimum adherence to HAART is critical to successful outcome of patients receiving therapy. At least 95% adherence to HAART is optimum and studies have shown that 50%. Important factors that influence adherence to HAART such as regimen related complexities, patient/family related issues and factors related to healthcare delivery system makes adherence to HAART challenging. Although numerous interventions to improve adherence have been investigated in developed as well as developing countries, majority of work in this area is focused on adherence in adults and data in children is limited. Therefore, in order to facilitate adherence and improve outcome of HAART in pediatric population, it is necessary to have a deep understanding of the factors influencing adherence and interventions that can improve adherence in children.
已证实高效抗逆转录病毒疗法（HAART）在抑制人类免疫缺陷病毒（HIV）复制、降低与HIV相关的发病率和死亡率以及改善感染HIV的成人和儿童的生活质量方面是有效的。然而，药物对不服用的患者不起作用，在HIV感染的管理中，目前已明确最佳坚持HAART对接受治疗的患者的成功治疗结果至关重要。至少95%坚持HAART是最佳的，研究表明50%。影响坚持HAART的重要因素，如治疗方案相关的复杂性、患者/家庭相关问题以及与医疗保健提供系统相关的因素，使得坚持HAART具有挑战性。尽管在发达国家和发展中国家都对众多改善坚持治疗的干预措施进行了研究，但该领域的大部分工作都集中在成人的坚持治疗上，儿童方面的数据有限。因此，为了促进儿童群体坚持HAART并改善治疗结果，有必要深入了解影响坚持治疗的因素以及可改善儿童坚持治疗的干预措施。
