Binette J P, Binette M B
Veterans Administration Medical Center, Buffalo, NY 14215.
Scanning Microsc. 1991 Dec;5(4):1029-34; discussion 1034-6.
We have extracted proteins from urinary tract stones by electrodialysis and have developed antisera to the core and the shell of a renal stone. The protein composition varies between stones but is identical in the core and the shell of the same stone. One stone antigen is present in the urine of normal individuals and stone formers, as well as in cholesterol gallstone extracts. Electron microscopy of the core of a urate-calcium oxalate stone before and after demineralization reveals a fibrillar structure associated with mineral deposits, as well as aggregates of crystals.
我们通过电渗析从尿路结石中提取了蛋白质，并制备了针对肾结石核心和外壳的抗血清。不同结石的蛋白质组成有所不同，但同一结石的核心和外壳中的蛋白质组成是相同的。一种结石抗原存在于正常个体和结石形成者的尿液中，以及胆固醇胆结石提取物中。对尿酸钙草酸盐结石核心脱矿前后进行电子显微镜观察，发现有与矿物质沉积相关的纤维状结构以及晶体聚集体。
