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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ferreira P C, Gonzaga C, Kroon E G, Dos-Santos J R, Bicalho H M, Golgher R R

Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Braz J Med Biol Res. 1991;24(1):21-7.

The molecular weight and the electrofocusing profile of human amniotic membrane interferon (IFN-AM) were determined. 2. When submitted to gel filtration, IFN-AM showed a single 26-28 kDa component; in polyacrylamide gel electrophoresis one component of 19,500. 3. In electrofocusing, IFN-AM displayed a heterogeneous profile with 5 to 7 peaks, but different from human alpha or beta IFNs. This heterogeneity was reduced by previous treatment of IFN-AM with neuraminidase. 4. IFN-AM is a sialoglycoprotein similar to human beta IFN in terms of antigenicity but different from it in electrofocusing profile.

测定了人羊膜干扰素（IFN-AM）的分子量和等电聚焦图谱。2. 进行凝胶过滤时，IFN-AM显示出单一的26 - 28 kDa组分；在聚丙烯酰胺凝胶电泳中为19,500的一个组分。3. 在等电聚焦中，IFN-AM呈现出具有5至7个峰的异质性图谱，但不同于人α或β干扰素。用神经氨酸酶预先处理IFN-AM可降低这种异质性。4. IFN-AM是一种唾液糖蛋白，在抗原性方面与人β干扰素相似，但在等电聚焦图谱上与之不同。

Ferreira P C, Gonzaga C, Kroon E G, Dos-Santos J R, Bicalho H M, Golgher R R

Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Braz J Med Biol Res. 1991;24(1):21-7.

The molecular weight and the electrofocusing profile of human amniotic membrane interferon (IFN-AM) were determined. 2. When submitted to gel filtration, IFN-AM showed a single 26-28 kDa component; in polyacrylamide gel electrophoresis one component of 19,500. 3. In electrofocusing, IFN-AM displayed a heterogeneous profile with 5 to 7 peaks, but different from human alpha or beta IFNs. This heterogeneity was reduced by previous treatment of IFN-AM with neuraminidase. 4. IFN-AM is a sialoglycoprotein similar to human beta IFN in terms of antigenicity but different from it in electrofocusing profile.

测定了人羊膜干扰素（IFN-AM）的分子量和等电聚焦图谱。2. 进行凝胶过滤时，IFN-AM显示出单一的26 - 28 kDa组分；在聚丙烯酰胺凝胶电泳中为19,500的一个组分。3. 在等电聚焦中，IFN-AM呈现出具有5至7个峰的异质性图谱，但不同于人α或β干扰素。用神经氨酸酶预先处理IFN-AM可降低这种异质性。4. IFN-AM是一种唾液糖蛋白，在抗原性方面与人β干扰素相似，但在等电聚焦图谱上与之不同。