Yoshikawa Y, Yamanouchi K, Takahashi R, Fujiwara K
Jpn J Med Sci Biol. 1975 Jun;28(3):189-200. doi: 10.7883/yoken1952.28.189.
Turmors induced in Japanese quails by the Schmidt-Ruppin strain of Rous sarcoma virus were examined histopathologically. The following three phases were recognized in the quails whose tumors regressed finally (regressor). Phase I was between days 4 and 7 of virus inoculation, when growth of tumor cells was seen with predominant infiltration of heterophils. Phase II, from days 10 to 14, was characterized by necrosis of tumor cells and focal accumulation of lymphoid cells which frequently formed follicle-like nodules. In phase III from days 18 to 24, tumor cells and heterophils disappeared, whereas diffuse infilitration of lymphoid cells, plasma cells and histiocytes were demonstrated. In the quails whose tumors progressed (progressor), growth of tumor cells and infiltration of heterophils at phase I seemed to follow a pattern similar to that of regressors, but subsequent infiltration and focal accumulation of lymphoid cells were rare. These morphological findings suggested an immunological reaction against tumor cells by lymphoid cells.
对施密特 - 鲁平株劳氏肉瘤病毒诱导日本鹌鹑产生的肿瘤进行了组织病理学检查。在最终肿瘤消退的鹌鹑（消退者）中识别出以下三个阶段。第一阶段在病毒接种后的第4天至第7天，可见肿瘤细胞生长，同时以嗜异性粒细胞的大量浸润为主。第二阶段从第10天至第14天，其特征为肿瘤细胞坏死以及淋巴细胞的局灶性聚集，这些淋巴细胞常形成滤泡样结节。在第18天至第24天的第三阶段，肿瘤细胞和嗜异性粒细胞消失，而可见淋巴细胞、浆细胞和组织细胞的弥漫性浸润。在肿瘤进展的鹌鹑（进展者）中，第一阶段肿瘤细胞的生长和嗜异性粒细胞的浸润似乎遵循与消退者相似的模式，但随后淋巴细胞的浸润和局灶性聚集很少见。这些形态学发现提示淋巴细胞对肿瘤细胞产生了免疫反应。
