Yamada A, Hayami M
Jpn J Med Sci Biol. 1981 Jun;34(3):161-8. doi: 10.7883/yoken1952.34.161.
In Japanese quails treated with chicken amniotic fluid (ChAmF) which had been previously shown to induce suppressor cells to natural killer (NK) cells, tumors appeared with shortened incubation periods after inoculation with Schmidt-Ruppin strain of Rous sarcoma virus (SR-RSV) compared with untreated quails. The tumors in ChAmF-treated quails subsequently grew in a similar pattern to those in untreated quails, whereas by challenging with a lower dose of the virus, enhanced tumor growth was observed as well as earlier onset of tumors in ChAmF-treated quails than in untreated ones. This enhancing effect on tumor growth due to suppression of NK-cell activity was transferred to normal quails with spleen cells obtained from ChAmF-treated quails, since RSV-induced tumors appeared earlier in the recipients of ChAmF-treated spleen cells than in those of untreated spleen cells. These findings show that suppression of NK-cell activity by ChAmF administration rendered quails higher susceptibility to tumor induction by SR-RSV challenge. In other words, NK-cell activity was strongly suggested to contribute to the early protection against tumor growth in the system of Rous sarcoma in Japanese quails.
在先前已证明能诱导抑制细胞作用于自然杀伤（NK）细胞的鸡羊水（ChAmF）处理过的日本鹌鹑中，与未处理的鹌鹑相比，接种劳氏肉瘤病毒施密特-鲁平株（SR-RSV）后肿瘤出现的潜伏期缩短。ChAmF处理过的鹌鹑中的肿瘤随后以与未处理鹌鹑中肿瘤相似的模式生长，然而，通过用较低剂量的病毒进行攻击，观察到ChAmF处理过的鹌鹑中肿瘤生长增强以及肿瘤比未处理的鹌鹑更早出现。由于NK细胞活性受到抑制而对肿瘤生长产生的这种增强作用，通过将从ChAmF处理过的鹌鹑获得的脾细胞转移到正常鹌鹑中得以体现，因为RSV诱导的肿瘤在接受ChAmF处理过的脾细胞的受体中比在未处理脾细胞的受体中出现得更早。这些发现表明，给予ChAmF抑制NK细胞活性使鹌鹑对SR-RSV攻击诱导肿瘤具有更高的易感性。换句话说，强烈提示NK细胞活性有助于在日本鹌鹑的劳氏肉瘤系统中对肿瘤生长进行早期保护。
