Abrahamian S, Fodor M, Görcs T, Galoyan A, Palkovits M
Institute of Biochemistry, Armenian Acad. Sci., Yerevan.
Acta Microbiol Hung. 1991;39(4):267-78.
The distribution of several neuropeptides in subepicardial atrial ganglia was examined in the rat heart by using immunohistochemical techniques. Some of the ganglion cells in the right atrium exhibited neuropeptide Y-immunoreactivity while no immunostaining was found with antisera against atrial natriuretic polypeptide (ANF), substance P, vasoactive intestinal polypeptide (VIP), and calcitonin gene-related peptide (CGRP). Nerve fibers in and around the ganglia showed neuropeptide Y, calcitonin gene-related peptide and vasoactive intestinal polypeptide immunoreactivities. Some of these immunoreactive fibers (substance P, calcitonin gene-related peptide, neuropeptide Y) formed relatively dense networks around blood vessels and capillaries. Atrial natriuretic polypeptide-like immunoreactivity which was present in atrial myocytes failed to show up in any neuronal elements in the rat heart.
采用免疫组织化学技术，研究了大鼠心脏心外膜下心房神经节中几种神经肽的分布情况。右心房的一些神经节细胞呈现神经肽Y免疫反应性，而针对心房利钠多肽（ANF）、P物质、血管活性肠肽（VIP）和降钙素基因相关肽（CGRP）的抗血清未发现免疫染色。神经节内及其周围的神经纤维显示出神经肽Y、降钙素基因相关肽和血管活性肠肽免疫反应性。其中一些免疫反应性纤维（P物质、降钙素基因相关肽、神经肽Y）在血管和毛细血管周围形成了相对密集的网络。心房肌细胞中存在的心房利钠多肽样免疫反应性在大鼠心脏的任何神经元成分中均未出现。
