Wekerle H, Engelhardt B, Risau W, Meyermann R
Max-Planck-Institute for Psychiatry, Munich, Federal Republic of Germany.
Brain Pathol. 1991 Jan;1(2):107-14. doi: 10.1111/j.1750-3639.1991.tb00647.x.
As a prerequisite of inflammatory lesion formation in (auto-)immune disease of the central nervous system, lymphocytes have to interact with brain endothelia. In recent years much progress has been made towards a better understanding of mechanisms and factors involved in organ specific homing of lymphocytes. Many lines of evidence indicate that T lymphocytes recognizing antigens which are exclusively beyond the blood-brain barrier cross this barrier only when they are in an activated state, irrespective of their antigen specificity. Antigen presentation by blood-brain barrier endothelia, however, may play a role in later stages of florid inflammation.
作为中枢神经系统（自身）免疫疾病中炎症病变形成的一个先决条件，淋巴细胞必须与脑内皮细胞相互作用。近年来，在更好地理解淋巴细胞器官特异性归巢所涉及的机制和因素方面已经取得了很大进展。许多证据表明，识别仅存在于血脑屏障之外抗原的T淋巴细胞只有在激活状态下才会穿过该屏障，而与其抗原特异性无关。然而，血脑屏障内皮细胞的抗原呈递可能在明显炎症的后期阶段起作用。
