Teng Yingqi, Zeisberg Michael, Kalluri Raghu
Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
J Clin Invest. 2007 Feb;117(2):304-6. doi: 10.1172/JCI31200.
It has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal phenotype, is a key event occurring during normal development and pathological processes. Multiple extracellular stimuli and transcriptional regulators can trigger EMT, but how such distinct signaling pathways orchestrate the complex cellular events that facilitate EMT is not well understood. In this issue of the JCI, Venkov et al. report on their examination of fibroblasts resulting from EMT and describe a novel protein-DNA complex that is essential for transcription of fibroblast-specific protein 1 (FSP1) and sufficient to induce early EMT events (see the related article beginning on page 482). Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome.
越来越明显的是，终末分化细胞的概念可能是一个简化的概念。上皮-间质转化（EMT）是上皮细胞呈现间质表型的过程，是正常发育和病理过程中发生的关键事件。多种细胞外刺激和转录调节因子可触发EMT，但这些不同的信号通路如何协调促进EMT的复杂细胞事件尚不清楚。在本期《临床研究杂志》中，文科夫等人报告了他们对EMT产生的成纤维细胞的研究，并描述了一种新型蛋白质-DNA复合物，该复合物对成纤维细胞特异性蛋白1（FSP1）的转录至关重要，并且足以诱导早期EMT事件（见第482页开始的相关文章）。总体而言，他们的结果表明该复合物是EMT转录组的重要调节因子。
