Ryan C M, Williams T M, Orchard T J, Finegold D N
Department of Psychiatry, University of Pittsburgh School of Medicine, PA.
Diabetes. 1992 Jan;41(1):107-13. doi: 10.2337/diab.41.1.107.
To test the hypothesis that diabetes mellitus is associated with cognitive dysfunction, a battery of neuropsychological tests was administered to 75 diabetic adults and an equal number of demographically similar nondiabetic control subjects. Compared with control subjects, diabetic subjects performed significantly more poorly on measures of psychomotor efficiency and spatial information processing. In contrast, no between-group differences appeared on measures of verbal intelligence, learning, memory, problem solving, or simple motor speed. Results from multiple regression analyses showed that clinically significant distal symmetrical polyneuropathy was strongly associated with psychomotor slowing, whereas, glycosylated hemoglobin values were weakly associated with both psychomotor slowing and spatial processing. No other biomedical variables predicted cognitive test performance. These neurobehavioral data are consistent with the hypothesis that a "central neuropathy" may be associated, at least in part, with chronic hyperglycemia.
为了验证糖尿病与认知功能障碍相关的假说，对75名成年糖尿病患者以及数量相同、人口统计学特征相似的非糖尿病对照者进行了一系列神经心理学测试。与对照者相比，糖尿病患者在心理运动效率和空间信息处理测试中的表现明显更差。相比之下，在语言智力、学习、记忆、问题解决或简单运动速度测试中，两组之间未出现差异。多元回归分析结果显示，具有临床意义的远端对称性多发性神经病变与心理运动迟缓密切相关，而糖化血红蛋白值与心理运动迟缓和空间处理能力均呈弱相关。没有其他生物医学变量能够预测认知测试表现。这些神经行为学数据与以下假说相符：“中枢神经病变”可能至少部分与慢性高血糖有关。
