Muller G, Goettsch C, Morawietz H
University of Technology, Medical Faculty Carl Gustav Carus, Department of Vascular Endothelium and Microcirculation, Fetscherstr. 74, 01307 Dresden, Germany.
Hamostaseologie. 2007 Feb;27(1):5-12.
This review focuses on the role of vascular oxidative stress in the development and progression of endothelial dysfunction. We discuss different sources of oxidative stress in the vessel wall, oxidative stress and coagulation, the role of oxidative stress and vascular function in arteries and veins, the flow-dependent regulation of reactive oxygen species, the putative impact of oxidative stress on atherosclerosis, the interaction of angiotensin II, oxidative stress and endothelial dysfunction, and clinical implications.
本综述聚焦于血管氧化应激在内皮功能障碍发生发展过程中的作用。我们讨论了血管壁氧化应激的不同来源、氧化应激与凝血、氧化应激在动脉和静脉中与血管功能的作用、活性氧的血流依赖性调节、氧化应激对动脉粥样硬化的潜在影响、血管紧张素 II、氧化应激与内皮功能障碍的相互作用以及临床意义。
