Filippi Luca, Schillaci Orazio
Department of Biopathology and Diagnostic Imaging, Univeristy of Rome Tor Vergata, Viale Mazzini 121, 00195 Rome, Italy.
Expert Rev Med Devices. 2006 Nov;3(6):699-703. doi: 10.1586/17434440.3.6.699.
Evaluation of: Bar-Shalom R, Yefremov N, Guralnik L et al. SPECT/CT using (67)Ga and (111)In-labeled leukocyte scintigraphy for diagnosis of infection. J. Nucl. Med. 47(4), 587-594 (2006). Labeled leukocytes and (67)Ga scan have been proved to be useful to image infectious and inflammatory processes. However, it is well known that nuclear imaging lacks precise anatomical landmarks. When highly specific tracers are used, the background activity may be too low to be used as a framework for spatial orientation. To overcome these drawbacks, the hybrid devices combining positron emission tomography/single photon emission computed tomography (SPECT) and computed tomography (CT) have been introduced, thereby providing a precise anatomical-functional correlation. The paper under evaluation highlights the emerging role of hybrid SPECT/CT to image infection with labeled leukocytes and (67)Ga. The authors suggest that fusion imaging can be of paramount value to locate the site of infection and to better define the extent of disease.
Bar-Shalom R、Yefremov N、Guralnik L等人所著的《使用（67）镓和（111）铟标记的白细胞闪烁显像的SPECT/CT用于感染诊断》。《核医学杂志》第47卷第4期，587 - 594页（2006年）。标记白细胞和（67）镓扫描已被证明对感染和炎症过程的成像很有用。然而，众所周知，核成像缺乏精确的解剖标志。当使用高特异性示踪剂时，本底活性可能过低，无法用作空间定位的框架。为克服这些缺点，已引入了结合正电子发射断层扫描/单光子发射计算机断层扫描（SPECT）和计算机断层扫描（CT）的混合设备，从而提供精确的解剖-功能相关性。所评估的论文强调了混合SPECT/CT在使用标记白细胞和（67）镓对感染进行成像方面的新兴作用。作者认为融合成像对于确定感染部位和更好地界定疾病范围可能具有至关重要的价值。
