Pavuk Marian, Patterson Donald G, Turner Wayman E, Needham Larry L, Ketchum Norma S
SpecPro Inc., 12500 San Pedro Avenue, Suite 670, San Antonio, TX 78216, USA.
Chemosphere. 2007 May;68(1):62-8. doi: 10.1016/j.chemosphere.2006.12.039. Epub 2007 Feb 5.
We measured levels of PCDDs, PCDFs, non-ortho, and mono-ortho substituted PCBs in 106 US Air Force Vietnam veterans, participants of the Air Force Health Study (AFHS) who attended the final medical examination in 2002. Twelve veterans were Ranch Hands involved in aerial spraying of herbicides in Vietnam (1962-1971), and 94 were Comparisons who flew transport missions in Southeast Asia (SEA) during the same time period. These veterans had no previous 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) measurement because they had not attended any of the previous AFHS examinations, or their previous measurements were missing or not valid. The mean TCDD levels in 2002 were 1.7 pg/g lipid in Comparisons and 5.5 pg/g lipid in Ranch Hands. The mean PCDD toxic equivalent - TEQ (1997) in Comparisons was 12.6 pg/g lipid, 5.4 pg/g lipid for PCDFs, 5.2 pg/g lipid for non-ortho PCBs, and 9.4 pg/g lipid for mono-ortho PCBs, with a total mean TEQ (1997) of 32.6 pg/g lipid. Corresponding mean TEQs in Ranch Hands were 15.5 pg/g lipid for PCDDs, 4.6 pg/g lipid for PCDFs, 2.2 pg/g lipid for non-ortho PCBs, and 9.3 pg/g lipid for mono-ortho PCBs, yielding the total mean TEQ (1997) of 31.6pg/g lipid. Using the re-evaluated 2005 WHO TEFs, the total mean TEQs (2005) decreased by about 28% in both Comparisons and Ranch Hands, to 23.6 pg/g lipid and 22.8 pg/g lipid, respectively. This was mainly due to changes of TEFs for the group of mono-ortho PCBs, which decreased the mono-ortho PCBs TEQs by almost 90% in both Ranch Hands and Comparisons.
我们测量了106名参加空军健康研究（AFHS）且于2002年参加最后一次体检的美国空军越战老兵体内的多氯二苯并二恶英（PCDDs）、多氯二苯并呋喃（PCDFs）、非邻位和单邻位取代多氯联苯（PCBs）的含量。12名老兵是参与1962 - 1971年越南除草剂空中喷洒任务的“牧场工人”，94名是同期在东南亚（SEA）执行运输任务的对照组。这些老兵之前没有进行过2,3,7,8 - 四氯二苯并对二恶英（TCDD）测量，因为他们之前没有参加过AFHS的任何检查，或者之前的测量结果缺失或无效。2002年对照组的平均TCDD含量为1.7皮克/克脂质，“牧场工人”组为5.5皮克/克脂质。对照组中PCDD的平均毒性当量 - TEQ（1997）为12.6皮克/克脂质，PCDF为5.4皮克/克脂质，非邻位PCBs为5.2皮克/克脂质，单邻位PCBs为9.4皮克/克脂质，总平均TEQ（1997）为32.6皮克/克脂质。“牧场工人”组中PCDD、PCDF、非邻位PCBs和单邻位PCBs对应的平均TEQ（1997）分别为15.5皮克/克脂质、4.6皮克/克脂质、2.2皮克/克脂质和9.3皮克/克脂质，总平均TEQ（1997）为31.6皮克/克脂质。使用2005年重新评估的世界卫生组织毒性当量因子（WHO TEFs）后，对照组和“牧场工人”组的总平均TEQ（2005）均下降了约28%，分别降至23.6皮克/克脂质和22.8皮克/克脂质。这主要是由于单邻位PCBs组毒性当量因子的变化，使得“牧场工人”组和对照组中该组的TEQ均下降了近90%。
