Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 55, Scuola Medica, 56126 Pisa, Italy.
Int J Mol Sci. 2014 May 5;15(5):7787-811. doi: 10.3390/ijms15057787.
The worldwide explosion of the rates of diabetes and other metabolic diseases in the last few decades cannot be fully explained only by changes in the prevalence of classical lifestyle-related risk factors, such as physical inactivity and poor diet. For this reason, it has been recently proposed that other "nontraditional" risk factors could contribute to the diabetes epidemics. In particular, an increasing number of reports indicate that chronic exposure to and accumulation of a low concentration of environmental pollutants (especially the so-called persistent organic pollutants (POPs)) within the body might be associated with diabetogenesis. In this review, the epidemiological evidence suggesting a relationship between dioxin and other POPs exposure and diabetes incidence will be summarized, and some recent developments on the possible underlying mechanisms, with particular reference to dioxin, will be presented and discussed.
在过去几十年中，全球范围内糖尿病和其他代谢性疾病的发病率呈爆炸式增长，仅用体力活动减少和饮食不良等经典生活方式相关风险因素的流行变化来解释是不够的。因此，最近有人提出，其他“非传统”风险因素可能导致糖尿病流行。特别是，越来越多的报告表明，人体慢性暴露于低浓度环境污染物（尤其是所谓的持久性有机污染物 (POPs)）并在体内积累，可能与糖尿病的发生有关。在这篇综述中，将总结流行病学证据表明二恶英和其他 POPs 暴露与糖尿病发病率之间的关系，并介绍和讨论一些关于潜在机制的最新进展，特别是关于二恶英的潜在机制。
