Jarour Najwa, Hayajneh Wail A, Balbeesi Adel, Otoom Haidar, Al-Shurman Abdullah, Kharabsheh Sa'ad
Directorate of Diseases Control and Prevention, Ministry of Health, Amman, Jordan.
Vaccine. 2007 May 4;25(18):3615-8. doi: 10.1016/j.vaccine.2007.01.058. Epub 2007 Jan 23.
This study was conducted to assess immunity (seroprevalence) to rubella among Jordanian women of childbearing age. A multistage cluster sampling was used to recruit 1125 women of childbearing age (15-49 year) from the 12 Governorates of Jordan. Anti-rubella antibody titers were measured using enzyme-linked immunoassays. The overall immunity rate to rubella among women in childbearing age was 90.9% (CI: 88.8-92.9). However, the immunity rate was significantly lower in younger women aged 15-19 years (83%) compared to the whole cohort (P</=0.001) which means potential increased risk for congenital rubella syndrome (CRS). Immunity rates did not differ between regions and between urban and rural areas. Since the main priority is to decrease CRS among relatively susceptible cohorts, we recommend modifying the existing Expanded Program on Immunization with inclusion of a second dose of rubella vaccine at school entry (6 years of age) to decrease circulation of the virus among susceptible young females. We also recommend yearly catch-up school vaccination of young females entering the 10th grade for the next 10 years. Strengthening of rubella and CRS surveillance programs is also recommended in parallel with pre-marriage counseling regarding rubella and CRS for young females.
本研究旨在评估约旦育龄妇女对风疹的免疫力（血清阳性率）。采用多阶段整群抽样方法，从约旦的12个省招募了1125名育龄妇女（15 - 49岁）。使用酶联免疫吸附测定法检测抗风疹抗体滴度。育龄妇女中风疹的总体免疫率为90.9%（置信区间：88.8 - 92.9）。然而，15 - 19岁的年轻女性的免疫率（83%）显著低于整个队列（P≤0.001），这意味着先天性风疹综合征（CRS）的潜在风险增加。不同地区以及城乡之间的免疫率没有差异。由于主要优先事项是降低相对易感人群中的CRS发生率，我们建议修改现有的扩大免疫规划，在入学时（6岁）纳入第二剂风疹疫苗，以减少病毒在易感年轻女性中的传播。我们还建议在未来10年对进入十年级的年轻女性进行年度学校补种疫苗。同时，建议加强风疹和CRS监测项目，并为年轻女性提供关于风疹和CRS的婚前咨询。
