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用于高位颈脊髓损伤后通过功能性电刺激恢复手臂和手部功能的神经假体的研发。

Development of a neuroprosthesis for restoring arm and hand function via functional electrical stimulation following high cervical spinal cord injury.

作者信息

Kirsch Robert

机构信息

Case Western Reserve University, Cleveland, OH 44106 USA (216-368-3158,

出版信息

Conf Proc IEEE Eng Med Biol Soc. 2005;2005:4142-4. doi: 10.1109/IEMBS.2005.1615375.

DOI:10.1109/IEMBS.2005.1615375
PMID:17281145
Abstract

This paper describes the development of an implanted neuroprosthesis for restoring hand and arm function to individuals with high level tetraplegia resulting from C1-C4 spinal cord injury. These individuals have complete paralysis below the level of the neck and are thus highly disabled. The neuroprosthesis under development will restore basic upper extremity movements needed for simple yet important daily activities such as eating and grooming. Simulations performed with a musculoskeletal model of the shoulder and elbow indicate that existing stimulation technology using a realistic number of stimulation channels should be sufficient for providing these functions. The neuroprosthesis will utilize 24 channels of stimulation, muscle-based electrodes for stimulation of hand muscles, and nerve cuff electrodes for stimulation of shoulder and elbow muscles. The two implanted stimulators also include a total of four implanted bipolar EMG recording channels that sample activity in neck and facial muscles. These signals, along with measurements of head orientation, will provide the user command interface for this system.

摘要

本文描述了一种植入式神经假体的研发,该假体旨在恢复因C1 - C4脊髓损伤导致高位截瘫的患者的手部和手臂功能。这些患者颈部以下完全瘫痪,因此严重残疾。正在研发的神经假体将恢复简单但重要的日常活动(如进食和梳洗)所需的基本上肢运动。使用肩部和肘部的肌肉骨骼模型进行的模拟表明,采用实际数量的刺激通道的现有刺激技术应足以提供这些功能。该神经假体将利用24个刺激通道、用于刺激手部肌肉的基于肌肉的电极以及用于刺激肩部和肘部肌肉的神经袖套电极。两个植入式刺激器还总共包括四个植入式双极肌电图记录通道,用于采集颈部和面部肌肉的活动。这些信号,连同头部方向的测量结果,将为该系统提供用户命令界面。

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引用本文的文献

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Implanted neuroprosthesis for assisting arm and hand function after stroke: a case study.植入式神经假体辅助中风后手臂和手部功能:一项病例研究。
J Rehabil Res Dev. 2012;49(10):1505-16. doi: 10.1682/jrrd.2011.09.0171.
2
A novel five degree of freedom user command controller in people with spinal cord injury and non-injured for full upper extremity neuroprostheses, wearable powered orthoses and prosthetics.一种新型的五自由度用户指令控制器,用于脊髓损伤患者和非损伤患者的全上肢神经假体、可穿戴动力矫形器和假肢。
Med Biol Eng Comput. 2013 Mar;51(3):317-30. doi: 10.1007/s11517-012-0996-3. Epub 2012 Dec 13.
3
Temporal coding of brain patterns for direct limb control in humans.
用于人类直接肢体控制的脑电模式的时间编码。
Front Neurosci. 2010 Jun 18;4. doi: 10.3389/fnins.2010.00034. eCollection 2010.
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Nerve cuff stimulation and the effect of fascicular organization for hand grasp in nonhuman primates.神经袖套刺激及束状结构对非人灵长类动物手部抓握的影响。
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1557-60. doi: 10.1109/IEMBS.2009.5332395.
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Spinal cord injury: present and future therapeutic devices and prostheses.脊髓损伤:当前及未来的治疗设备与假肢
Neurotherapeutics. 2008 Jan;5(1):147-62. doi: 10.1016/j.nurt.2007.10.062.