血管紧张素转换酶抑制剂致胎儿病变：长期预后
Angiotensin-converting enzyme inhibitor fetopathy: long-term outcome.
作者信息
Laube Guido F, Kemper Markus J, Schubiger Gregor, Neuhaus Thomas J
机构信息
University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2007 Sep;92(5):F402-3. doi: 10.1136/adc.2006.101717. Epub 2007 Feb 6.
Abstract
Fetal exposure to angiotensin-converting enzyme inhibitors (ACEIs) is associated with increased neonatal morbidity and mortality. Long-term follow-up of three patients with fetal ACEI exposure revealed impaired renal function in two, severe hypertension and proteinuria in one and isolated polycythaemia in all three. Careful long-term follow-up of children with ACEI fetopathy is recommended.
摘要
胎儿暴露于血管紧张素转换酶抑制剂（ACEI）与新生儿发病率和死亡率增加有关。对三名有胎儿ACEI暴露史的患者进行长期随访发现，其中两名肾功能受损，一名出现严重高血压和蛋白尿，三名均有单纯性红细胞增多症。建议对患有ACEI胎儿病的儿童进行仔细的长期随访。
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