酮咯酸的水性、油性和软膏制剂：对前列腺素E2诱导的眼部炎症的疗效及安全性：技术说明
Aqueous, oil, and ointment formulations of ketorolac: efficacy against prostaglandin E2-induced ocular inflammation and safety: a technical note.
作者信息
Malhotra Manjusha, Majumdar Dipak K
机构信息
Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy, University of Delhi, Pushp Vihar, Sector III, New Delhi-110017, India.
出版信息
AAPS PharmSciTech. 2006;7(4):96. doi: 10.1208/pt070496.
Abstract
The efficacy of aqueous, oil, and ointment formulations of ketorolac against PGE-induced ocular inflammation in rabbits was evaluated, with monitoring of blinking rate and PMN and protein migration in tear fluid, following topical PGE instillation. Ketorolac ophthalmic formulations protected the eye against inflammatory insult. Chronic topical administration of formulations for 10 days into rats' eyes did not lead to any appreciable gastrointestinal ulceration, which indicates that the formulations are safe for long-term use.
摘要
评估了酮咯酸的水性、油性和软膏制剂对前列腺素（PGE）诱导的兔眼炎症的疗效，在局部滴注PGE后，监测眨眼频率以及泪液中中性粒细胞（PMN）和蛋白质的迁移情况。酮咯酸眼用制剂可保护眼睛免受炎性损伤。将制剂对大鼠眼睛进行为期10天的长期局部给药，未导致任何明显的胃肠道溃疡，这表明该制剂可长期安全使用。
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