Tatsuta M, Iishi H, Baba M, Taniguchi H
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Int J Cancer. 1992 Jan 2;50(1):108-11. doi: 10.1002/ijc.2910500122.
The effects of ad libitum feeding of synthetic, low-protein diets on the incidence, number and histology of colon tumors induced by azoxymethane (AOM), on the norepinephrine concentration in the colon wall tissue and on the labelling index of colon mucosa were investigated in Wistar rats. Rats received 10 weekly injections of 7.4 mg/kg body weight of AOM and were given synthetic diets of equal calorie content containing 25% casein (normal-protein diet), 10% casein (low-protein diet) or 5% casein (very-low-protein diet). Administration of the low- and very-low-protein diets resulted in significant increases in the incidence and number of colon tumors at week 30. However, it did not affect the histology of the colon tumors. The low- and very-low-protein diets also resulted in significant increases in norepinephrine concentration in the proximal and distal portions of the colon wall and in the labelling indices of both parts of the colon mucosa. Our findings indicate that low- and very-low-protein diets enhance colon carcinogenesis and that this may be related to their effects in increasing the norepinephrine level in the colon wall and in stimulating proliferation of colon epithelial cells.
在Wistar大鼠中，研究了随意喂食合成低蛋白饮食对由氧化偶氮甲烷（AOM）诱导的结肠肿瘤的发生率、数量和组织学、结肠壁组织中去甲肾上腺素浓度以及结肠黏膜标记指数的影响。大鼠每周接受10次7.4mg/kg体重的AOM注射，并给予热量含量相等的合成饮食，其中含有25%酪蛋白（正常蛋白饮食）、10%酪蛋白（低蛋白饮食）或5%酪蛋白（极低蛋白饮食）。在第30周时，给予低蛋白和极低蛋白饮食导致结肠肿瘤的发生率和数量显著增加。然而，它并未影响结肠肿瘤的组织学。低蛋白和极低蛋白饮食还导致结肠壁近端和远端部分去甲肾上腺素浓度以及结肠黏膜两部分的标记指数显著增加。我们的研究结果表明，低蛋白和极低蛋白饮食会增强结肠癌发生，这可能与其增加结肠壁去甲肾上腺素水平以及刺激结肠上皮细胞增殖的作用有关。
