神经降压素对由氧化偶氮甲烷诱导的大鼠结肠实验性致癌作用的增强效应。
Enhancement by neurotensin of experimental carcinogenesis induced in rat colon by azoxymethane.
作者信息
Tasuta M, Iishi H, Baba M, Taniguchi H
机构信息
Department of Gastrointestinal Oncology, The Center for Adult Diseases, Osaka, Japan.
出版信息
Br J Cancer. 1990 Sep;62(3):368-71. doi: 10.1038/bjc.1990.299.
Abstract
The effects of neurotensin on the incidence, number, size, and histology of colon tumours induced by azoxymethane (AOM) were investigated in Wistar rats. Rats were given 10 weekly injections of AOM (7.4 mg kg-1 body weight) and were also given 200 micrograms kg-1 of neurotensin in depot form every other day until the end of the experiment. In week 40, prolonged alternate-day administration of neurotensin resulted in significant increases in the number and size of colon tumours and the incidence of adenocarcinomas penetrating muscle layer and deeper. However, neurotensin did not influence the incidence of tumour-bearing rats and the histological appearance of colon tumours. Administration of neurotensin caused a significant increase in the labelling index of the colon cancers but not that of colon mucosa. These findings indicate that neurotensin enhanced the growth of colon tumours, possibly related to its effect in increasing proliferation of colon cancer cells.
摘要
在Wistar大鼠中研究了神经降压素对由氧化偶氮甲烷（AOM）诱导的结肠肿瘤的发生率、数量、大小和组织学的影响。给大鼠每周注射10次AOM（7.4毫克/千克体重），并且每隔一天给予200微克/千克的长效神经降压素，直至实验结束。在第40周时，长期隔日给予神经降压素导致结肠肿瘤的数量和大小以及穿透肌层及更深层的腺癌发生率显著增加。然而，神经降压素不影响荷瘤大鼠的发生率和结肠肿瘤的组织学外观。给予神经降压素导致结肠癌的标记指数显著增加，但结肠黏膜的标记指数未增加。这些发现表明，神经降压素促进了结肠肿瘤的生长，这可能与其增加结肠癌细胞增殖的作用有关。
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