Iishi H, Tatsuta M, Baba M, Iseki K, Uehara H, Nakaizumi A
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Cancer Lett. 1995 Jul 20;94(1):49-54. doi: 10.1016/0304-3835(95)03823-f.
The effects of peptide histidine isoleucine (PHI) on the incidence and histology of colon tumors induced by azoxymethane (AOM), and on the labeling index of colon mucosa were investigated in Wistar rats. Rats received weekly s.c. injections of 7.4 mg/kg body weight of AOM for 10 weeks, and of 1.0 or 4.0 nmol/kg body weight of PHI until the end of the experiment in week 35. Administration of PHI at the higher, but not the lower dosage, significantly increased the incidence of colon tumors. PHI had no influence on the histology of colon tumors or adenocarcinomas. It also caused significant increase in the labeling index of colon epithelial cells. These findings indicate that PHI enhances colon carcinogenesis, and that its effect may be related to increasing proliferation of colon epithelial cells.
在Wistar大鼠中，研究了肽组氨酸异亮氨酸（PHI）对由氧化偶氮甲烷（AOM）诱导的结肠肿瘤的发生率和组织学，以及对结肠黏膜标记指数的影响。大鼠每周皮下注射7.4mg/kg体重的AOM，共10周，并在第35周实验结束前，每周皮下注射1.0或4.0nmol/kg体重的PHI。较高剂量而非较低剂量的PHI给药显著增加了结肠肿瘤的发生率。PHI对结肠肿瘤或腺癌的组织学没有影响。它还导致结肠上皮细胞的标记指数显著增加。这些发现表明，PHI增强了结肠癌的发生，其作用可能与结肠上皮细胞增殖增加有关。
