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艾滋病相关结核病中的支气管肺泡中性粒细胞、干扰素γ诱导蛋白10和白细胞介素-7

Bronchoalveolar neutrophils, interferon gamma-inducible protein 10 and interleukin-7 in AIDS-associated tuberculosis.

作者信息

Kibiki G S, Myers L C, Kalambo C F, Hoang S B, Stoler M H, Stroup S E, Houpt E R

机构信息

Medical Department and Radiology Department, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

出版信息

Clin Exp Immunol. 2007 May;148(2):254-9. doi: 10.1111/j.1365-2249.2007.03330.x. Epub 2007 Feb 7.

DOI:10.1111/j.1365-2249.2007.03330.x
PMID:17286802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1868885/
Abstract

During advanced AIDS tuberculosis (TB) often presents atypically with smear-negative and non-cavitary disease, yet immune features associated with this change are poorly characterized. We examined the local immune response in a cohort of Tanzanian AIDS-associated TB patients who underwent bronchoalveolar lavage. TB infection was confirmed in bronchoalveolar lavage (BAL) fluid by culture, probe and polymerase chain reaction (PCR). Among TB patients CD4 count correlated positively with the extent of cavitary disease as well as BAL TB load (qPCR C(T)). TB patients had significantly higher granulocyte-macrophage colony-stimulating factor (GM-CSF) than non-TB patients, and those with non-cavitary TB had significantly higher BAL interferon gamma-inducible protein (IP-10) and interleukin (IL)-7 than those with cavities. BAL neutrophils were as prevalent as monocytes/macrophages or epithelial cells, and immunohistochemistry revealed that neutrophils, monocytes/macrophages, and epithelial cells were major sources of the IP-10 and IL-7. These data suggest a dysregulated cytokine profile may contribute to the TB of advanced AIDS.

摘要

在晚期艾滋病患者中，结核病（TB）通常表现为非典型症状，痰涂片阴性且无空洞形成，但与此变化相关的免疫特征却鲜有描述。我们对一组接受支气管肺泡灌洗的坦桑尼亚艾滋病相关结核病患者的局部免疫反应进行了研究。通过培养、探针和聚合酶链反应（PCR）在支气管肺泡灌洗（BAL）液中确诊了结核感染。在结核病患者中，CD4细胞计数与空洞性病变的程度以及BAL液中的结核负荷（定量PCR C(T)值）呈正相关。结核病患者的粒细胞巨噬细胞集落刺激因子（GM-CSF）显著高于非结核病患者，非空洞性结核病患者的BAL液中干扰素γ诱导蛋白（IP-10）和白细胞介素（IL）-7显著高于有空洞的患者。BAL液中的中性粒细胞与单核细胞/巨噬细胞或上皮细胞一样普遍，免疫组织化学显示中性粒细胞、单核细胞/巨噬细胞和上皮细胞是IP-10和IL-7的主要来源。这些数据表明细胞因子谱失调可能导致晚期艾滋病患者发生结核病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/1868885/abdbb9f9d93d/cei0148-0254-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/1868885/b97ba290157d/cei0148-0254-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/1868885/abdbb9f9d93d/cei0148-0254-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/1868885/b97ba290157d/cei0148-0254-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b143/1868885/abdbb9f9d93d/cei0148-0254-f2.jpg

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