SP110基因多态性与南非人群的肺结核无关。
SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population.
作者信息
Babb C, Keet E Hanekom, van Helden P D, Hoal E G
机构信息
Molecular Biology and Human Genetics, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, MRC Centre for Molecular and Cellular Biology, Stellenbosch University, Tygerberg, 7505, Cape Town, South Africa.
出版信息
Hum Genet. 2007 May;121(3-4):521-2. doi: 10.1007/s00439-007-0335-1. Epub 2007 Feb 8.
Susceptibility to tuberculosis (TB) in mice has recently been attributed to the Ipr1 gene. Polymorphisms in the human homologue, SP110, have been investigated in various populations with only one study finding an association with TB susceptibility. We investigated eight SP110 polymorphisms in a South African population, including two novel polymorphisms. No significant association was found with any of the polymorphisms investigated, including two polymorphisms that were previously found to be associated with TB susceptibility in West African populations.
小鼠对结核病（TB）的易感性最近被归因于Ipr1基因。已在不同人群中对人类同源基因SP110的多态性进行了研究，仅有一项研究发现其与结核病易感性有关联。我们在南非人群中调查了8个SP110多态性，包括两个新的多态性。未发现所研究的任何多态性与结核病存在显著关联，其中包括先前在西非人群中发现与结核病易感性相关的两个多态性。
Zotero 插件