Simplified synthesis of 3-(1-arylsulfonylalkyl) indoles and their reaction with Reformatsky reagents.
作者信息
Palmieri Alessandro, Petrini Marino
机构信息
Dipartimento di Scienze Chimiche, Universita di Camerino, via S. Agostino 1, I-62032 Camerino, Italy.
出版信息
J Org Chem. 2007 Mar 2;72(5):1863-6. doi: 10.1021/jo062538e. Epub 2007 Feb 9.
PMID:17288482
Abstract
A simple procedure for the preparation of 3-(1-arylsulfonyl-alkyl) indoles by three-component condensation of indoles, carbonyls, and arenesulfinic acids is presented. The obtained products undergo a Reformatsky reaction leading to alkyl 3-(3-indolyl) alkanoates and (3-indolyl) ketones.
摘要
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