通过底物的随机、周期性和稳定来源对酵母振荡糖酵解的控制：模型与实验研究
Control of oscillating glycolysis of yeast by stochastic, periodic, and steady source of substrate: a model and experimental study.
作者信息
Boiteux A, Goldbeter A, Hess B
出版信息
Proc Natl Acad Sci U S A. 1975 Oct;72(10):3829-33. doi: 10.1073/pnas.72.10.3829.
Abstract
Type and range of entrainment of glycolytic oscillations by a periodic source of substrate are determined experimentally in yeast extracts. Subharmonic entrainment proves the nonlinear nature of the glycolytic oscillator Random variation of the substrate input yields sustained oscillations of irregular waveform and stable period. The results agree with the predictions of an allosteric model for phosphofructokinase (EC 2.7.1.11; ATP:D-fructose-6-phosphate 1-phosphotransferase), which is the enzyme responsible for periodic operation of glycolysis. A comparison between model and experiment in the case of a constant source of substrate further indicates that the oscillatory dynamics of the glycolytic system can satisfactorily be described by the phosphofructokinase model.
摘要
通过实验确定了在酵母提取物中周期性底物源对糖酵解振荡的夹带类型和范围。次谐波夹带证明了糖酵解振荡器的非线性性质。底物输入的随机变化产生不规则波形和稳定周期的持续振荡。这些结果与磷酸果糖激酶（EC 2.7.1.11；ATP：D-果糖-6-磷酸1-磷酸转移酶）的变构模型预测相符，该酶负责糖酵解的周期性运作。在恒定底物源情况下模型与实验的比较进一步表明，磷酸果糖激酶模型能够令人满意地描述糖酵解系统的振荡动力学。
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