变构酶模型中的时空组织模式。
Patterns of spatiotemporal organization in an allosteric enzyme model.
作者信息
Goldbeter A
出版信息
Proc Natl Acad Sci U S A. 1973 Nov;70(11):3255-9. doi: 10.1073/pnas.70.11.3255.
Abstract
The behavior of a model for an allosteric enzyme oscillator activated by the reaction product is analyzed in the presence of diffusion. When the concentrations of the chemicals are fixed at the boundaries, dynamic dissipative structures are shown to arise in the form of propagating concentration waves. The model is applied to the phosphofructokinase reaction and suggests that a spatiotemporal organization may originate at a macroscopic (supracellular) level from the glycolytic system.
摘要
在存在扩散的情况下，分析了由反应产物激活的变构酶振荡器模型的行为。当化学物质的浓度在边界处固定时，动态耗散结构以传播的浓度波的形式出现。该模型应用于磷酸果糖激酶反应，并表明时空组织可能起源于糖酵解系统的宏观（细胞外）水平。
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本文引用的文献
1
Spiral waves of chemical activity.化学活动的螺旋波。
Science. 1972 Feb 11;175(4022):634-6. doi: 10.1126/science.175.4022.634.
2
Concentration wave propagation in two-dimensional liquid-phase self-oscillating system.二维液相自振荡系统中的浓度波传播
Nature. 1970 Feb 7;225(5232):535-7. doi: 10.1038/225535b0.
3
ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL.关于别构转变的本质：一个合理的模型。
J Mol Biol. 1965 May;12:88-118. doi: 10.1016/s0022-2836(65)80285-6.
4
A CHEMICAL MECHANISM FOR OSCILLATION OF GLYCOLYTIC INTERMEDIATES IN YEAST CELLS.酵母细胞中糖酵解中间产物振荡的化学机制
Proc Natl Acad Sci U S A. 1964 Jun;51(6):989-94. doi: 10.1073/pnas.51.6.989.
5
Diffusion in embryogenesis.胚胎发生中的扩散
Nature. 1970 Jan 31;225(5231):420-2. doi: 10.1038/225420a0.
6
Control of developing fields.发育场的控制
Annu Rev Biophys Bioeng. 1972;1:409-64. doi: 10.1146/annurev.bb.01.060172.002205.
7
A phase-shift model for the spatial and temporal organization of developing systems.一种用于发育系统时空组织的相移模型。
J Theor Biol. 1969 Oct;25(1):49-107. doi: 10.1016/s0022-5193(69)80017-2.
8
Positional information and the spatial pattern of cellular differentiation.位置信息与细胞分化的空间模式。
J Theor Biol. 1969 Oct;25(1):1-47. doi: 10.1016/s0022-5193(69)80016-0.
9
Control of reduced diphosphopyridine nucleotide oscillations in beef heart extracts. I. Effects of modifiers of phosphofructokinase activity.牛肉心提取物中还原二磷酸吡啶核苷酸振荡的控制。I. 磷酸果糖激酶活性调节剂的作用。
Arch Biochem Biophys. 1968 Apr;125(1):151-6. doi: 10.1016/0003-9861(68)90649-8.
10
Dissipative structures for an allosteric model. Application to glycolytic oscillations.变构模型的耗散结构。在糖酵解振荡中的应用。
Biophys J. 1972 Oct;12(10):1302-15. doi: 10.1016/S0006-3495(72)86164-2.
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