在患有精神分裂症的年轻首发患者及临床上未受影响的同胞中未发现P50抑制缺陷。
Failure to find P50 suppression deficits in young first-episode patients with schizophrenia and clinically unaffected siblings.
作者信息
de Wilde O M, Bour L J, Dingemans P M, Koelman J H T M, Linszen D H
机构信息
Department of Psychiatry, Academic Medical Centre, University of Amsterdam, Tafelbergweg 25, 1105 BC, Amsterdam, The Netherlands.
出版信息
Schizophr Bull. 2007 Nov;33(6):1319-23. doi: 10.1093/schbul/sbm001. Epub 2007 Feb 7.
Abstract
OBJECTIVE
To evaluate whether the P50 gating deficit is present in young first-episode patients with schizophrenia and their healthy young siblings.
METHODS
An auditory paired-click paradigm was used to assess P50 gating in 53 patients, 27 unaffected siblings, and 28 healthy controls. P50 parameters were compared between patients, sibs, and unrelated controls by a mixed-effects regression model.
RESULTS
P50 gating was not significantly impaired in patients with schizophrenia and healthy siblings as compared with controls.
CONCLUSIONS
P50 gating was not found to be significantly impaired in young first-episode schizophrenia patients and in healthy young siblings. These results are in contrast with the existing literature. We suggest that P50 gating impairment may be developmentally or age dependent.
摘要
目的
评估首发精神分裂症的年轻患者及其健康的年轻同胞中是否存在P50门控缺陷。
方法
采用听觉配对点击范式评估53例患者、27名未患病同胞和28名健康对照者的P50门控。通过混合效应回归模型比较患者、同胞和无关对照者之间的P50参数。
结果
与对照组相比，精神分裂症患者及其健康同胞的P50门控未受到显著损害。
结论
在首发精神分裂症的年轻患者及其健康的年轻同胞中未发现P50门控受到显著损害。这些结果与现有文献相反。我们认为P50门控损害可能与发育或年龄有关。
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