Srivastava Jyoti, Barber Diane L, Jacobson Matthew P
Department of Cell and Tissue Biology, Unicversity of California-San Francisco, San Francisco, CA, USA.
Physiology (Bethesda). 2007 Feb;22:30-9. doi: 10.1152/physiol.00035.2006.
Changes in intracellular pH regulate many cell behaviors, including proliferation, migration, and transformation. However, our understanding of how physiological changes in pH affect protein conformations and macromolecular assemblies is limited. We present design principles, current modeling predictions, and examples of pH sensors or proteins that have activities or ligand-binding affinities that are regulated by changes in intracellular pH.
细胞内pH值的变化调节许多细胞行为，包括增殖、迁移和转化。然而，我们对pH值的生理变化如何影响蛋白质构象和大分子组装的理解是有限的。我们提出了设计原则、当前的模型预测，以及pH传感器或蛋白质的实例，这些传感器或蛋白质具有受细胞内pH值变化调节的活性或配体结合亲和力。
