Williamson Morgan, Moustaid-Moussa Naima, Gollahon Lauren
Department of Biological Sciences, Texas Tech University, Lubbock, TX, United States.
Department of Nutrition Sciences, Texas Tech University, Lubbock, TX, United States.
Front Mol Med. 2021 Nov 16;1:777088. doi: 10.3389/fmmed.2021.777088. eCollection 2021.
Metabolic diseases are becoming more common and more severe in populations adhering to western lifestyle. Since metabolic conditions are highly diet and lifestyle dependent, it is suggested that certain diets are the cause for a wide range of metabolic dysfunctions. Oxidative stress, excess calcium excretion, inflammation, and metabolic acidosis are common features in the origins of most metabolic disease. These primary manifestations of "metabolic syndrome" can lead to insulin resistance, diabetes, obesity, and hypertension. Further complications of the conditions involve kidney disease, cardiovascular disease, osteoporosis, and cancers. Dietary analysis shows that a modern "Western-style" diet may facilitate a disruption in pH homeostasis and drive disease progression through high consumption of exogenous acids. Because so many physiological and cellular functions rely on acid-base reactions and pH equilibrium, prolonged exposure of the body to more acids than can effectively be buffered, by chronic adherence to poor diet, may result in metabolic stress followed by disease. This review addresses relevant molecular pathways in mammalian cells discovered to be sensitive to acid - base equilibria, their cellular effects, and how they can cascade into an organism-level manifestation of Metabolic Syndromes. We will also discuss potential ways to help mitigate this digestive disruption of pH and metabolic homeostasis through dietary change.
在遵循西方生活方式的人群中，代谢性疾病正变得越来越普遍且越来越严重。由于代谢状况高度依赖饮食和生活方式，有人认为某些饮食是多种代谢功能障碍的成因。氧化应激、钙排泄过多、炎症和代谢性酸中毒是大多数代谢性疾病发病过程中的常见特征。“代谢综合征”的这些主要表现可导致胰岛素抵抗、糖尿病、肥胖症和高血压。这些病症的进一步并发症包括肾脏疾病、心血管疾病、骨质疏松症和癌症。饮食分析表明，现代的“西式”饮食可能会因大量摄入外源性酸而破坏pH稳态并推动疾病进展。由于许多生理和细胞功能依赖于酸碱反应和pH平衡，长期通过长期坚持不良饮食使身体暴露于超过可有效缓冲量的酸中，可能会导致代谢应激继而引发疾病。本综述探讨了在哺乳动物细胞中发现的对酸碱平衡敏感的相关分子途径、它们的细胞效应，以及它们如何级联成代谢综合征的机体水平表现。我们还将讨论通过饮食改变来帮助减轻这种pH消化紊乱和代谢稳态的潜在方法。
