Li C, Gefter W B
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Chest. 1992 Jan;101(1):102-4. doi: 10.1378/chest.101.1.102.
Three schizophrenic adults with previous histories of using phenothiazine derivatives developed acute pulmonary edema after taking large amounts of these drugs. The clinical manifestations included coma (three), hypothermia (two), tachycardia (two), miosis (two) and hypotension (one). All three patients underwent gastric lavage and were treated supportively. The fulminant pulmonary edema in the three cases resolved within 18 to 40 h. The etiology of pulmonary edema following overdosage of phenothiazines remains unknown. The authors hypothesize that the most likely pathogenesis is a drug-induced neurogenic pulmonary edema resulting from a disturbance of hypothalamic function.
三名有使用吩噻嗪衍生物病史的成年精神分裂症患者在大量服用这些药物后发生了急性肺水肿。临床表现包括昏迷（3例）、体温过低（2例）、心动过速（2例）、瞳孔缩小（2例）和低血压（1例）。所有三名患者均接受了洗胃并给予支持治疗。三例暴发性肺水肿在18至40小时内消退。吩噻嗪过量后肺水肿的病因仍不清楚。作者推测，最可能的发病机制是药物诱发的神经源性肺水肿，由下丘脑功能紊乱所致。
