Salob S P, Laverty A, Atherton D J
Department of Dermatology, Hospitals for Sick Children, London, England.
Pediatrics. 1993 Jan;91(1):13-6.
Using histamine provocation tests, bronchial responsiveness was measured in 43 children with atopic dermatitis, aged 7 to 15 years, who had attended pediatric dermatology clinics within the past 5 years. The children were divided into two groups, one group of 21 children in whom asthma had been previously diagnosed and in whom symptoms of asthma had occurred in the preceding year, and the other comprising 22 children who denied any such symptoms. Bronchial hyperresponsiveness (as defined by a 20% fall in forced expiratory volume in 1 second at a provoking dose of histamine of 7.8 mumol or less [PD20]) was demonstrated in all but 1 of the children with atopic dermatitis and asthma, in 18 of the 22 children with atopic dermatitis alone, but in only 3 of a control group of 18 children without atopic dermatitis or asthma. The asthmatic subjects (median PD20 = 0.22 mumol) had more severe bronchial hyperresponsiveness than the nonasthmatic subjects (median PD20 = 2.10 mumol). This study confirms the strong association between atopic dermatitis and bronchial hyperresponsiveness, even in the absence of overt asthmatic symptoms.
采用组胺激发试验，对43名7至15岁、过去5年内曾就诊于儿科皮肤科门诊的特应性皮炎患儿进行支气管反应性测定。这些患儿被分为两组，一组21名患儿先前已被诊断为哮喘且在前一年出现过哮喘症状，另一组由22名否认有任何此类症状的患儿组成。除1名特应性皮炎合并哮喘患儿外，其余所有患儿均表现出支气管高反应性（以组胺激发剂量为7.8微摩尔或更低时1秒用力呼气量下降20%[PD20]来定义）；22名单纯特应性皮炎患儿中有18名表现出支气管高反应性，而在18名无特应性皮炎或哮喘的对照组儿童中只有3名表现出支气管高反应性。哮喘患儿（中位PD20 = 0.22微摩尔）的支气管高反应性比非哮喘患儿（中位PD20 = 2.10微摩尔）更严重。这项研究证实了即使没有明显的哮喘症状，特应性皮炎与支气管高反应性之间也存在密切关联。
