Arifhodzic Nermina A, Mahmoud Fadia F, Abul Habib T, Haines David D, Al-Dowaisan Abdel Rahman, Ammar Islam M, Novotny Ladislav, Wise John A
Al-Rashed Allergy Center, Sabah Hospital, Kuwait.
Arch Environ Occup Health. 2005 Sep-Oct;60(5):243-7. doi: 10.3200/AEOH.60.5.243-247.
The authors evaluate major immunologic features of asthma and allergies in a Kuwaiti population. They analyzed peripheral venous blood from 17 asthmatic and 17 healthy long-term residents of Kuwait by using two-color flow cytometry for major lymphocyte subpopulations; they also evaluated 10 healthy individuals who had recently arrived in Kuwait. Relative to healthy subjects, asthmatics exhibited increased percentages of T+ NK cells (p < .01), T-helper cells (p < .05), T-cytotoxic and NK cells for both total numbers (p < .01-.001) and percentages (p < .05-.01), and increased percentages of T cells expressing CD54 (ICAM-1; p < .001) and CD62 (L-selectin; p < .01). However, B cells were present at significantly lower levels in asthmatics, both in total numbers (p < .05) and percentages (p < .01). In comparison with healthy individuals who had recently arrived in Kuwait, healthy long-term residents exhibited elevated numbers of pan-T cells (p < .01) and T-helper cells (p < .05). These results help establish immunological parameters for asthma and allergies in Kuwaiti populations.
作者评估了科威特人群中哮喘和过敏的主要免疫学特征。他们通过使用双色流式细胞术分析17名科威特哮喘患者和17名健康长期居民的外周静脉血中的主要淋巴细胞亚群；他们还评估了10名刚抵达科威特的健康个体。与健康受试者相比，哮喘患者的T + NK细胞百分比增加（p < 0.01）、辅助性T细胞增加（p < 0.05）、细胞毒性T细胞和NK细胞的总数（p < 0.01 - 0.001）和百分比均增加（p < 0.05 - 0.01），并且表达CD54（细胞间黏附分子-1；p < 0.001）和CD62（L-选择素；p < 0.01）的T细胞百分比增加。然而，哮喘患者的B细胞数量和百分比均显著降低（总数，p < 0.05；百分比，p < 0.01）。与刚抵达科威特的健康个体相比，健康长期居民的全T细胞（p < 0.01）和辅助性T细胞数量增加（p < 0.05）。这些结果有助于确定科威特人群中哮喘和过敏的免疫学参数。
