来自显脉香茶菜的对映-贝壳杉烷二萜类化合物

ent-Kaurane Diterpenoids from Isodon nervosus.

作者信息

Li Li-Mei, Li Guo-You, Ding Li-Sheng, Yang Li-Bin, Zhao Yong, Pu Jian-Xin, Xiao Wei-Lie, Han Quan-Bin, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2008 Apr;71(4):684-8. doi: 10.1021/np800027a. Epub 2008 Mar 18.

DOI:10.1021/np800027a

PMID:18345641

Abstract

A pentacyclic ent-kauranoid, nervonin A ( 1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J ( 2- 10), along with 10 known ones ( 11- 20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.

摘要

从显脉香茶菜中分离得到一个具有前所未有的环丁烷结构单元的五环对映-贝壳杉烷型二萜，神经酰胺A（1），以及其他九个新的对映-贝壳杉烷型二萜，神经酰胺B-J（2-10），还有10个已知化合物（11-20）。通过详细的光谱分析阐明了它们的结构。对所有二萜化合物针对K562、A549和HepG2人细胞系的细胞毒性进行了测定。化合物2、11、16、17和20表现出显著的细胞毒性。