Fleming D M, Elliot A J, Cross K W
Birmingham Research Unit of the Royal College of General Practitioners, Birmingham, UK.
Epidemiol Infect. 2007 Oct;135(7):1099-108. doi: 10.1017/S0950268807007881. Epub 2007 Feb 12.
We compared the burden of illness due to a spectrum of respiratory diagnostic categories among persons presenting in a sentinel general practice network in England and Wales during periods of influenza and of respiratory syncytial virus (RSV) activity. During all periods of viral activity, incidence rates of influenza-like illness, bronchitis and common cold were elevated compared to those in baseline periods. Excess rates per 100,000 of acute bronchitis were greater in children aged <1 year (median difference 2702, 95% CI 929-4867) and in children aged 1-4 years (994, 95% CI 338-1747) during RSV active periods rather than influenza; estimates for the two viruses were similar in other age groups. Excess rates of influenza-like illness in all age groups were clearly associated with influenza virus activity. For common cold the estimates of median excess rates were significantly higher in RSV active periods for the age groups <1 year (3728, 95% CI 632-5867) and 5-14 years (339, 95% CI 59-768); estimates were similar in other age groups for the two viruses. The clinical burden of disease associated with RSV is as great if not greater than influenza in patients of all ages presenting to general practitioners.
我们比较了在英格兰和威尔士一个哨点全科医疗网络中就诊的人群在流感和呼吸道合胞病毒（RSV）活跃期间，一系列呼吸道诊断类别所致的疾病负担。在病毒活跃的所有时期，与基线期相比，流感样疾病、支气管炎和普通感冒的发病率均有所升高。在RSV活跃期而非流感期，每10万例急性支气管炎的超额发病率在<1岁儿童中更高（中位数差异2702，95%置信区间929 - 4867），在1 - 4岁儿童中也更高（994，95%置信区间338 - 1747）；在其他年龄组中，两种病毒的估计值相似。所有年龄组流感样疾病的超额发病率与流感病毒活动明显相关。对于普通感冒，在<1岁年龄组（3728，95%置信区间632 - 5867）和5 - 14岁年龄组（339，95%置信区间59 - 768）中，RSV活跃期的中位数超额发病率估计值显著更高；在其他年龄组中，两种病毒的估计值相似。对于就诊于全科医生的所有年龄段患者，与RSV相关的疾病临床负担即便不比流感更大，也与流感相当。
