Mayr Manuel, Madhu Basetti, Xu Qingbo
Cardiovascular Division, King's College, London SE5 9NU, UK.
Trends Cardiovasc Med. 2007 Feb;17(2):43-8. doi: 10.1016/j.tcm.2006.11.004.
Proteomics and metabolomics offer a nonbiased suite of tools to address pathophysiologic mechanisms from various levels by integrating signal transduction, cellular metabolism, and phenotype analysis. To link alterations of cellular proteins to metabolism and function, we have recently combined proteomic and metabolomic techniques. Examples, including genetic manipulation, ischemic preconditioning, atherosclerosis, and stem cell differentiation, are discussed to illustrate how the combination of these updated technologies may advance our understanding of cardiovascular biology.
蛋白质组学和代谢组学提供了一套无偏向性的工具，通过整合信号转导、细胞代谢和表型分析，从各个层面研究病理生理机制。为了将细胞蛋白质的变化与代谢和功能联系起来，我们最近结合了蛋白质组学和代谢组学技术。文中讨论了包括基因操作、缺血预处理、动脉粥样硬化和干细胞分化等例子，以说明这些最新技术的结合如何推动我们对心血管生物学的理解。
