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富马酸盐或富马酸盐代谢物可恢复细菌包膜旋转鞭毛的切换能力。

Fumarate or a fumarate metabolite restores switching ability to rotating flagella of bacterial envelopes.

作者信息

Barak R, Eisenbach M

机构信息

Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.

出版信息

J Bacteriol. 1992 Jan;174(2):643-5. doi: 10.1128/jb.174.2.643-645.1992.

DOI:10.1128/jb.174.2.643-645.1992
PMID:1729255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC205763/
Abstract

Flagella of cytoplasm-free envelopes of Escherichia coli or Salmonella typhimurium can rotate in either the counterclockwise or clockwise direction, but they never switch from one direction of rotation to another. Exogenous fumarate, in the intracellular presence of the chemotaxis protein CheY, restored switching ability to envelopes, with a concomitant increase in clockwise rotation. An increase in clockwise rotation was also observed after fumarate was added to partially lysed cells of E. coli, but the proportion of switching cells remained unchanged.

摘要

大肠杆菌或鼠伤寒沙门氏菌无细胞质包膜的鞭毛可以逆时针或顺时针方向旋转，但它们从不从一个旋转方向切换到另一个方向。在外源延胡索酸存在且细胞内有趋化蛋白CheY的情况下，包膜恢复了切换能力，同时顺时针旋转增加。将延胡索酸添加到部分裂解的大肠杆菌细胞中后，也观察到顺时针旋转增加，但切换细胞的比例保持不变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4238/205763/65f11ba42716/jbacter00068-0312-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4238/205763/fb313d12ec29/jbacter00068-0312-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4238/205763/65f11ba42716/jbacter00068-0312-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4238/205763/fb313d12ec29/jbacter00068-0312-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4238/205763/65f11ba42716/jbacter00068-0312-b.jpg

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Fumarate or a fumarate metabolite restores switching ability to rotating flagella of bacterial envelopes.富马酸盐或富马酸盐代谢物可恢复细菌包膜旋转鞭毛的切换能力。
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Bacterial cell envelopes with functional flagella.具有功能性鞭毛的细菌细胞壁。
J Biol Chem. 1981 Aug 25;256(16):8807-14.
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通过富马酸盐和富马酸还原酶调节细菌鞭毛旋转方向的机制。
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J Mol Biol. 2012 Feb 17;416(2):192-207. doi: 10.1016/j.jmb.2011.12.027. Epub 2011 Dec 19.
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Identification of Archaea-specific chemotaxis proteins which interact with the flagellar apparatus.与鞭毛装置相互作用的古菌特异性趋化蛋白的鉴定。
BMC Microbiol. 2009 Mar 16;9:56. doi: 10.1186/1471-2180-9-56.
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