Soltani Nepton, Keshavarz Manssor, Dehpour Ahmad Reza
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R., Iran.
Eur J Pharmacol. 2007 Apr 10;560(2-3):201-5. doi: 10.1016/j.ejphar.2006.12.020. Epub 2007 Jan 19.
Approximately one-third of patients with type 1 diabetes develop a variety of complications as a result of mechanisms that are not completely understood. However, insufficient metabolic control seems to play a major role. Other factors such as magnesium (Mg) could also be of importance. We designed this study to elucidate the effect of oral magnesium administration on plasma lipid profile and mesenteric fat in male Wistar rats. Animals were divided into 4 groups (n=10 in each group): one group served as control, while the other groups were made diabetic with a single i.v. injection of 40 mg/kg streptozocin. Animals in which the diabetic state lasted for 10 days were referred as acute diabetic rats, whereas those in which the diabetes lasted for 8 weeks were defined as chronic diabetics. Mg-treated chronic diabetic received 10 g/l of MgSO(4) added to the drinking water (0.46 g/24 h) for eight weeks following which the left common carotid artery was cannulated for continuous recording of blood pressure. Blood glucose, magnesium and lipid profiles levels were also determined. Diabetes induction caused plasma glucose, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), total cholesterol and triglyceride concentrations to increase, however plasma Mg level was decreased. Administration of MgSO(4) for eight weeks caused the return of the above factors to their normal levels. Mg concentrations also increased but failed to reach normal levels. Diabetes induction caused mesenteric fat/body weight ratio to increase, but administration of MgSO(4) reduced the ratio to normal levels. In addition, Mg administration returned systolic blood pressure to the normal level. Our results support the hypothesis that Mg may play a part in the management of diabetes and the prevention of its vascular complications in streptozocin-induced diabetic rats and it may be useful in the treatment of hyperlipidaemia in diabetic case.
大约三分之一的1型糖尿病患者会因一些尚未完全明了的机制而出现各种并发症。然而，代谢控制不佳似乎起着主要作用。其他因素如镁（Mg）可能也很重要。我们设计了这项研究，以阐明口服镁对雄性Wistar大鼠血浆脂质谱和肠系膜脂肪的影响。动物被分为4组（每组n = 10）：一组作为对照组，而其他组通过单次静脉注射40 mg/kg链脲佐菌素诱导糖尿病。糖尿病状态持续10天的动物被称为急性糖尿病大鼠，而糖尿病持续8周的动物被定义为慢性糖尿病大鼠。接受镁治疗的慢性糖尿病大鼠在接下来的八周内饮用添加了10 g/l MgSO₄的水（0.46 g/24 h），之后通过左颈总动脉插管连续记录血压。还测定了血糖、镁和脂质谱水平。糖尿病诱导导致血浆葡萄糖、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、总胆固醇和甘油三酯浓度升高，然而血浆镁水平降低。给予MgSO₄八周使上述因素恢复到正常水平。镁浓度也有所升高，但未达到正常水平。糖尿病诱导导致肠系膜脂肪/体重比增加，但给予MgSO₄可将该比值降至正常水平。此外，给予镁可使收缩压恢复到正常水平。我们的结果支持这样的假设，即镁可能在链脲佐菌素诱导的糖尿病大鼠的糖尿病管理和血管并发症预防中发挥作用，并且可能对糖尿病患者的高脂血症治疗有用。
