Hoffman J M, Hanson M W, Friedman H S, Hockenberger B M, Oakes W J, Halperin E C, Coleman R E
Department of Radiology, Duke University Medical Center, Durham, NC 27710.
J Comput Assist Tomogr. 1992 Jan-Feb;16(1):62-8. doi: 10.1097/00004728-199201000-00011.
Seventeen pediatric patients with posterior fossa brain tumors were studied with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET). The FDG uptake was ranked by two observers, and the results were correlated with tumor histology. Increased FDG uptake was associated with more malignant and aggressive tumor types. Heterogeneity of FDG uptake was associated with previous therapy, including radiation therapy and chemotherapy. 2-[18F]Fluoro-2-deoxy-D-glucose PET will likely be an important adjunct in the management of pediatric posterior fossa tumors, much as in adult patients with brain tumors.
对17例患有后颅窝脑肿瘤的儿科患者进行了2-[18F]氟-2-脱氧-D-葡萄糖（FDG）和正电子发射断层扫描（PET）研究。两名观察者对FDG摄取情况进行了分级，并将结果与肿瘤组织学进行关联。FDG摄取增加与更恶性和侵袭性更强的肿瘤类型相关。FDG摄取的异质性与先前的治疗有关，包括放射治疗和化疗。2-[18F]氟-2-脱氧-D-葡萄糖PET很可能会成为儿科后颅窝肿瘤治疗中的一项重要辅助手段，就如同在成人大脑肿瘤患者中一样。
