Ortutay Csaba, Siermala Markku, Vihinen Mauno
Institute of Medical Technology, University of Tampere, 33014, Tampere, Finland.
Immunogenetics. 2007 May;59(5):333-48. doi: 10.1007/s00251-007-0191-0. Epub 2007 Feb 9.
Many genes and proteins are required to carry out the processes of innate and adaptive immunity. For many studies, including systems biology, it is necessary to have a clear and comprehensive definition of the immune system, including the genes and proteins that take part in immunological processes. We have identified and cataloged a large portion of the human immunology-related genes, which we call the essential immunome. The 847 identified genes and proteins were annotated, and their chromosomal localizations were compared to the mouse genome. Relation to disease was also taken into account. We identified numerous pseudogenes, many of which are expressed, and found two putative new genes. We also carried out an evolutionary analysis of immune processes based on gene orthologs to gain an overview of the evolutionary past and molecular present of the human immune system. A list of genes and proteins were compiled. A comprehensive characterization of the member genes and proteins, including the corresponding pseudogenes is presented. Immunome genes were found to have three types of emergence in independent studies of their ontologies, domains, and functions.
许多基因和蛋白质参与先天性免疫和适应性免疫过程。对于包括系统生物学在内的许多研究而言，有必要对免疫系统进行清晰而全面的定义，包括参与免疫过程的基因和蛋白质。我们已经鉴定并编目了很大一部分人类免疫相关基因，我们将其称为必需免疫组。对鉴定出的847个基因和蛋白质进行了注释，并将它们的染色体定位与小鼠基因组进行了比较。还考虑了与疾病的关系。我们鉴定出了许多假基因，其中许多是可表达的，还发现了两个假定的新基因。我们还基于基因直系同源物对免疫过程进行了进化分析，以全面了解人类免疫系统的进化历程和分子现状。编制了一份基因和蛋白质清单。对成员基因和蛋白质进行了全面表征，包括相应的假基因。在对免疫组基因的本体、结构域和功能的独立研究中，发现它们有三种出现类型。
