Anderson C T, Westgard J O, Schlimgen K, Birnbaum M L
Am J Clin Pathol. 1977 Jul;68(1):63-7. doi: 10.1093/ajcp/68.1.63.
Arterial blood samples from 202 critically ill patients were studied. Lactate concentration, PO2, PCO2, pH, oxygen saturation, total CO2, and toe temperature were measured. Base excess, buffer base, actual bicarbonate, and standard bicarbonate were calculated. Analysis of the initial data obtained from each patient revealed that lactate concentration alone could not be used to predict survival. Elevations in lactate concentrations were observed in all types of acid-base disturbances. Survival was lowest (30%) for patients in metabolic acidosis with respiratory compensation, mean lactate concentration 10.5 mEq/l (mmol/l), and highest (65%) for patients in uncompensated respiratory alkalosis, mean lactate concentration, 2.57 mEq/l (mmol/l). Knowing the type of acid-base disturbance is necessary to evaluate the significance of elevated blood lactate values.
对202例危重症患者的动脉血样本进行了研究。测量了乳酸浓度、氧分压、二氧化碳分压、pH值、血氧饱和度、总二氧化碳和趾温。计算了碱剩余、缓冲碱、实际碳酸氢盐和标准碳酸氢盐。对从每位患者获得的初始数据进行分析后发现，仅乳酸浓度不能用于预测生存情况。在所有类型的酸碱紊乱中均观察到乳酸浓度升高。代谢性酸中毒伴呼吸代偿患者的生存率最低（30%），平均乳酸浓度为10.5 mEq/l（mmol/l），而未代偿性呼吸性碱中毒患者的生存率最高（65%），平均乳酸浓度为2.57 mEq/l（mmol/l）。了解酸碱紊乱的类型对于评估血乳酸值升高的意义是必要的。
