Danesh John, Saracci Rodolfo, Berglund Göran, Feskens Edith, Overvad Kim, Panico Salvatore, Thompson Simon, Fournier Agnès, Clavel-Chapelon Françoise, Canonico Marianne, Kaaks Rudolf, Linseisen Jakob, Boeing Heiner, Pischon Tobias, Weikert Cornelia, Olsen Anja, Tjønneland Anne, Johnsen Søren Paaske, Jensen Majken Karoline, Quirós Jose R, Svatetz Carlos Alberto Gonzalez, Pérez Maria-José Sánchez, Larrañaga Nerea, Sanchez Carmen Navarro, Iribas Concepción Moreno, Bingham Sheila, Khaw Kay-Tee, Wareham Nick, Key Timothy, Roddam Andrew, Trichopoulou Antonia, Benetou Vassiliki, Trichopoulos Dimitrios, Masala Giovanna, Sieri Sabina, Tumino Rosario, Sacerdote Carlotta, Mattiello Amalia, Verschuren W M Monique, Bueno-de-Mesquita H Bas, Grobbee Diederick E, van der Schouw Yvonne T, Melander Olle, Hallmans Göran, Wennberg Patrik, Lund Eiliv, Kumle Merethe, Skeie Guri, Ferrari Pietro, Slimani Nadia, Norat Teresa, Riboli Elio
EPIC-Heart Secretariat, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK.
Eur J Epidemiol. 2007;22(2):129-41. doi: 10.1007/s10654-006-9096-8. Epub 2007 Feb 13.
EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition (EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle (especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants (366,521 women and 153,457 men, mostly aged 35-70 years) in 23 centres in 10 European countries commenced follow-up for cause- specific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.
“欧洲癌症与营养前瞻性调查（EPIC）”中的心血管疾病研究部分（EPIC-Heart）是一项多中心前瞻性队列研究，旨在探究营养与主要慢性病结局之间的关系。其目标是通过充分利用EPIC中信息量异常丰富的数据库和生物样本，进一步了解生活方式（尤其是饮食）、环境、代谢和遗传因素在心血管疾病发生过程中的单独及综合影响。1992年至2000年间，来自欧洲10个国家23个中心的519,978名参与者（366,521名女性和153,457名男性，多数年龄在35至70岁之间）开始随访特定病因死亡率、癌症发病率和主要心血管疾病发病率。通过定量问卷或半定量食物频率问卷收集饮食信息，其中包括一项24小时饮食回顾子研究，以帮助校准饮食测量。收集了有关身体活动、吸烟、饮酒、职业史、社会经济地位和既往病史的信息。大多数参与者进行了人体测量和血压记录。从385,747人中采集了血样，分离出血浆、血清、红细胞和血沉棕黄层部分，并进行分装以便长期保存。到2004年，估计已记录了10,000例致命和非致命的冠心病及中风事件。EPIC-Heart分析的第一个周期将评估冠状动脉死亡率与几种主要饮食假说以及既定心血管危险因素之间的关联。后续分析将把这种方法扩展到非致命心血管结局以及更多饮食、生化和遗传因素。
