Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
Dietary Exposure Assessment Group, International Agency for Research on Cancer, Lyon, France.
Ann Oncol. 2013 Oct;24(10):2645-2651. doi: 10.1093/annonc/mdt255. Epub 2013 Jul 14.
In 1994, acrylamide (AA) was classified as a probable human carcinogen by the International Agency for Research on Cancer. In 2002, AA was discovered at relatively high concentrations in some starchy, plant-based foods cooked at high temperatures.
A prospective analysis was conducted to evaluate the association between the dietary intake of AA and ductal adenocarcinoma of the exocrine pancreatic cancer (PC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort using Cox regression modeling. EPIC includes >500,000 men and women aged 35-75 at enrollment from 10 European countries. AA intake was estimated for each participant by combining questionnaire-based food consumption data with a harmonized AA database derived from the EU monitoring database of AA levels in foods, and evaluated in quintiles and continuously.
After a mean follow-up of 11 years, 865 first incident adenocarcinomas of the exocrine pancreas were observed and included in the present analysis. At baseline, the mean dietary AA intake in EPIC was 26.22 µg/day. No overall association was found between continuous or quintiles of dietary AA intake and PC risk in EPIC (HR:0.95, 95%CI:0.89-1.01 per 10 µg/day). There was no effect measure modification by smoking status, sex, diabetes, alcohol intake or geographic region. However, there was an inverse association (HR: 0.73, 95% CI: 0.61-0.88 per 10 µg/day) between AA intake and PC risk in obese persons as defined using the body mass index (BMI, ≥ 30 kg/m(2)), but not when body fatness was defined using waist and hip circumference or their ratio.
Dietary intake of AA was not associated with an increased risk of PC in the EPIC cohort.
1994 年，国际癌症研究机构将丙烯酰胺（AA）归类为可能的人类致癌物。2002 年，在一些高温烹饪的淀粉类植物性食物中发现 AA 含量较高。
采用 Cox 回归模型对欧洲癌症与营养前瞻性调查（EPIC）队列中 AA 饮食摄入量与外分泌胰腺导管腺癌（PC）风险之间的关系进行了前瞻性分析。EPIC 队列包括来自 10 个欧洲国家的 50 多万名年龄在 35-75 岁的男性和女性。每位参与者的 AA 摄入量均通过结合基于问卷的食物消费数据和源自欧盟食品 AA 水平监测数据库的协调 AA 数据库进行估计，并以五分位数和连续变量进行评估。
平均随访 11 年后，观察到 865 例外分泌胰腺腺首例腺癌病例，并纳入本分析。在基线时，EPIC 中 AA 的平均膳食摄入量为 26.22 µg/天。连续或五分位数的 AA 摄入量与 PC 风险在 EPIC 中均无相关性（HR：0.95，95%CI：0.89-1.01/10 µg/天）。吸烟状况、性别、糖尿病、饮酒或地理位置均未影响测量效果。然而，在肥胖人群（BMI≥30 kg/m2）中，AA 摄入量与 PC 风险呈负相关（HR：0.73，95%CI：0.61-0.88/10 µg/天），但在根据腰围和臀围或其比值定义肥胖时，未观察到这种相关性。
EPIC 队列中 AA 的饮食摄入量与 PC 风险增加无关。
