Jiang Wei-Wu, Su Shih-Horng, Eberhart Robert C, Tang Liping
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
J Biomed Mater Res A. 2007 Aug;82(2):492-7. doi: 10.1002/jbm.a.31175.
Although many biodegradable polymers, such as poly-L-lactic acid and poly-L-glycolic acid, are preferentially composed of biological residues normally present in the human body, implants made of these materials often trigger inflammatory and fibrotic responses. Unfortunately, the mechanisms involved in degradable material-mediated tissue responses remain largely unknown. Using animal implantation and cell culture system models, we found a strong correlation between the rate of material degradation and the degree of inflammatory response to material implants. Furthermore, we have identified that both water-soluble and water-insoluble degradation products are potent triggers of phagocyte activation, including at the least, superoxide production. These results support a new concept that slow degradation may improve the biocompatibility of degradable drug-releasing particles and tissue engineering scaffolds.
尽管许多可生物降解的聚合物，如聚-L-乳酸和聚-L-乙醇酸，优先由人体中通常存在的生物残基组成，但由这些材料制成的植入物常常引发炎症和纤维化反应。不幸的是，可降解材料介导的组织反应所涉及的机制在很大程度上仍然未知。利用动物植入和细胞培养系统模型，我们发现材料降解速率与对材料植入物的炎症反应程度之间存在很强的相关性。此外，我们已经确定，水溶性和水不溶性降解产物都是吞噬细胞激活的有效触发因素，至少包括超氧化物的产生。这些结果支持了一个新的概念，即缓慢降解可能会提高可降解药物释放颗粒和组织工程支架的生物相容性。
