Vleggaar Danny, Fitzgerald Rebecca, Lorenc Z Paul
J Drugs Dermatol. 2014 Apr;13(4 Suppl):s29-31.
Poly-L-lactic acid (PLLA) is a synthetic, biocompatible, biodegradable polymer. For its use in soft tissue augmentation, it is supplied as a lyophilized powder containing PLLA microparticles, the size and chemical attributes of which are tightly controlled. As a biocompatible material, PLLA generates a desired subclinical inflammatory tissue response that leads to encapsulation of the microparticles, stimulation of host collagen production, and fibroplasia. Over time, the PLLA degrades, the inflammatory response wanes, and host collagen production increases. This response leads to the generation of new volume and structural support that occurs in a gradual, progressive manner, and which can last for years. Coupled with consistent, optimized injection methodology, the use of PLLA in soft tissue augmentation can result in a predictable cosmetic effect that is completely controlled by the treating clinician.
聚左旋乳酸（PLLA）是一种合成的、生物相容的、可生物降解的聚合物。用于软组织填充时，它以含有PLLA微粒的冻干粉末形式提供，其大小和化学属性受到严格控制。作为一种生物相容性材料，PLLA会引发预期的亚临床炎症组织反应，导致微粒被包裹、刺激宿主胶原蛋白生成以及纤维组织增生。随着时间推移，PLLA降解，炎症反应减弱，宿主胶原蛋白生成增加。这种反应会以渐进的方式产生新的体积和结构支撑，且可持续数年。结合一致、优化的注射方法，PLLA在软组织填充中的应用可产生可预测的美容效果，完全由治疗医生掌控。
