Muraishi O, Ikado S, Yamashita T, Yamaguchi K, Ogawa A
Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan.
J Urol. 1992 Jan;147(1):242-5. doi: 10.1016/s0022-5347(17)37205-1.
Six dogs underwent bladder augmentation using an isolated flap of the body of the stomach after a supratrigonal cystectomy. Each dog was followed for six months with periodic determinations of urine pH, blood chemistry, cystometry and cystography. Postoperatively, urine pH decreased markedly after a meal in most dogs. No persistent hypergastrinemia was found. Autopsy showed that histological erosions developed in the bladder remnant in five dogs, and an ulcer in the bladder remnant in one dog. These results indicate that when an isolated, vagally denervated gastric segment is incorporated into the bladder, acid secretion from the segment may ulcerate the bladder.
六只狗在进行膀胱三角上切除术之后，使用胃体的孤立皮瓣进行膀胱扩大术。每只狗随访六个月，定期测定尿液pH值、血液化学、膀胱测压和膀胱造影。术后，大多数狗进食后尿液pH值显著下降。未发现持续性高胃泌素血症。尸检显示，五只狗的膀胱残余部分出现组织学糜烂，一只狗的膀胱残余部分出现溃疡。这些结果表明，当一个孤立的、去迷走神经支配的胃段并入膀胱时，该段的酸分泌可能会使膀胱发生溃疡。
