使用亚磷酸三苯酯 - 卤素类试剂温和合成卤代乙烯和偕二卤化物。
A mild synthesis of vinyl halides and gem-dihalides using triphenyl phosphite-halogen-based reagents.
作者信息
Spaggiari Alberto, Vaccari Daniele, Davoli Paolo, Torre Giovanni, Prati Fabio
机构信息
Dipartimento di Chimica, Università di Modena e Reggio Emilia, via Campi 183, 41100 Modena, Italy.
出版信息
J Org Chem. 2007 Mar 16;72(6):2216-9. doi: 10.1021/jo061346g. Epub 2007 Feb 13.
PMID:17295542
Abstract
A new application of (PhO)3P-halogen-based reagents to the synthesis of vinyl halides and gem-dihalides is described. Vinyl halides were prepared in good to excellent yields from enolizable ketones, whereas aldehydes afforded the corresponding gem-dihalides. The halogenation proceeded smoothly under mild conditions.
摘要
描述了(PhO)3P-卤素类试剂在卤代乙烯和偕二卤化物合成中的新应用。可烯醇化的酮能以良好至优异的产率制备卤代乙烯，而醛则生成相应的偕二卤化物。卤化反应在温和条件下顺利进行。
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