Hofstra Julie L, Poremba Kelsey E, Shimozono Alex M, Reisman Sarah E
The Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Angew Chem Int Ed Engl. 2019 Oct 14;58(42):14901-14905. doi: 10.1002/anie.201906815. Epub 2019 Sep 19.
A Ni-catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench-stable Ni(OAc) ⋅4 H O as a precatalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either 1,5-cyclooctadiene or 4-(N,N-dimethylamino)pyridine.
开发了一种镍催化的烯醇三氟甲磺酸酯卤化反应，该反应能在温和的反应条件下合成多种烯基碘化物、溴化物和氯化物。该反应使用廉价、易于保存的Ni(OAc)₂·4H₂O作为预催化剂，在亚化学计量的锌以及1,5-环辛二烯或4-(N,N-二甲基氨基)吡啶存在下于室温下进行。
