Lai H Henry, Hsu Elias I, Teh Bin S, Butler E Brian, Boone Timothy B
Scott Department of Urology, Baylor College of Medicine, and Department of Radiotherapy, Methodist Hospital, Houston, Texas 77030, USA.
J Urol. 2007 Mar;177(3):1021-5. doi: 10.1016/j.juro.2006.10.062.
We reviewed 13 years of experience with artificial urinary sphincter implantation (narrow backed cuff) at a single institution.
Between 1992 and 2005, 270 patients underwent artificial urinary sphincter implantation, as performed by a single surgeon at Baylor College of Medicine, and followup data were available on 218 of them. Mean followup was 36.5 months (maximum 151.4). Of the 218 patients 60 underwent prostatectomy and pelvic radiation, 116 underwent prostatectomy without radiotherapy, 11 had neurogenic bladder and 31 underwent secondary artificial urinary sphincter implantation.
The complication rate did not differ among the 4 treatment groups. Complication rates were infection in 5.5% of cases, erosion in 6.0%, urethral atrophy in 9.6%, mechanical failure in 6.0% and surgical removal or revision in 27.1%. Median time to complications was 3.7 months for infection, 19.8 months for erosion, 29.6 months for atrophy, 68.1 months for failure and 14.4 months for surgery. At 5 years 75% of patients were free from revision or removal. A history of failed injectable or male sling, or of Valsalva voiding did not adversely impact the outcome. The rate of bladder neck contracture was high in artificial urinary sphincter candidates, especially in irradiated patients (36% and 57%, respectively). Patients with prior pelvic radiation continued to be at higher risk for contracture recurrence after artificial urinary sphincter implantation (12%). Two-stage UroLume stent and artificial urinary sphincter placement offered long-term contracture and continence control in 8 of 11 patients with recurrent anastomotic contractures.
An artificial urinary sphincter is durable treatment for sphincter deficiency even in patients with a history of complications, neurogenic bladder, pelvic radiation, bladder neck contracture, Valsalva voiding, or failed injectables or slings.
我们回顾了在单一机构进行人工尿道括约肌植入术(窄背袖套)13年的经验。
1992年至2005年间,270例患者接受了人工尿道括约肌植入术,由贝勒医学院的一名外科医生实施,其中218例患者有随访数据。平均随访时间为36.5个月(最长151.4个月)。218例患者中,60例接受了前列腺切除术和盆腔放疗,116例接受了前列腺切除术但未接受放疗,11例患有神经源性膀胱,31例接受了二次人工尿道括约肌植入术。
4个治疗组的并发症发生率无差异。并发症发生率分别为感染5.5%、侵蚀6.0%、尿道萎缩9.6%、机械故障6.0%、手术取出或翻修27.1%。感染并发症的中位时间为3.7个月,侵蚀为19.8个月,萎缩为29.6个月,故障为68.1个月,手术为14.4个月。5年后,75%的患者无需翻修或取出。可注射药物或男性吊带失败史或瓦尔萨尔瓦排尿史对结果无不利影响。人工尿道括约肌候选患者的膀胱颈挛缩率较高,尤其是接受放疗的患者(分别为36%和57%)。既往接受盆腔放疗的患者在人工尿道括约肌植入术后挛缩复发的风险仍然较高(12%)。11例复发性吻合口挛缩患者中有8例通过两阶段UroLume支架和人工尿道括约肌置入实现了长期挛缩和控尿。
即使对于有并发症史、神经源性膀胱、盆腔放疗、膀胱颈挛缩、瓦尔萨尔瓦排尿、可注射药物或吊带失败的患者,人工尿道括约肌也是治疗括约肌功能不全的持久方法。