MUM1表达将滤泡性淋巴瘤分为主要为MUM1阴性的低级别亚型和MUM1阳性的高级别亚型。
MUM1 expression dichotomises follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes.
作者信息
Naresh Kikkeri N
出版信息
Haematologica. 2007 Feb;92(2):267-8. doi: 10.3324/haematol.10682.
PMID:17296585
Abstract
We investigated the expression of MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4) in 46 cases of follicular lymphoma (FL) and correlated this with grade and expression of CD10, Bcl-6 and Ki-67. The analysis suggests that MUM1 expression dichotomises FL into low-grade FL of CD10+/Bcl-6+/MUM1-/Ki-67low phenotype, and high-grade FL of CD10+/- /Bcl-6+/weak/MUM1+/ Ki-67high phenotype.
摘要
我们研究了46例滤泡性淋巴瘤（FL）中MUM1（多发性骨髓瘤癌基因1）/IRF4（干扰素调节因子4）的表达情况，并将其与CD10、Bcl-6和Ki-67的分级及表达相关联。分析表明，MUM1表达将FL分为具有CD10+/Bcl-6+/MUM1-/Ki-67低表型的低级别FL，以及具有CD10+/- /Bcl-6+/弱阳性/MUM1+/ Ki-67高表型的高级别FL。
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