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低剂量放疗（2 Gy×2）治疗扁桃体滤泡性淋巴瘤的全身远隔效应。

Systemic Abscopal Effect of Low-dose Radiotherapy (2 Gy ×2) against Palatine Tonsil Follicular Lymphoma.

机构信息

Department of Hematology, Kochi Medical School, Kochi University, Japan.

Department of Laboratory Medicine, Kochi Medical School Hospital, Kochi University, Japan.

出版信息

Intern Med. 2022 Oct 15;61(20):3107-3110. doi: 10.2169/internalmedicine.8968-21. Epub 2022 Mar 19.

DOI:10.2169/internalmedicine.8968-21
PMID:35314548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9646336/
Abstract

A 52-year-old man presented with palatine tonsillar swelling caused by follicular lymphoma. His tumor burden was low, but exacerbation of snoring and dysphagia was observed. Considering the first wave of coronavirus disease 2019 (COVID-19) pandemic, he received palliative 4-Gy irradiation to the tonsils in 2 fractions, which induced partial regression of tonsillar swellings and eradication of the circulating lymphoma cells. We suggest that low-dose radiotherapy triggered an abscopal effect of lymphoma, which allowed the patient time to receive COVID-19 vaccination before starting immunosuppressive chemo-immunotherapy.

摘要

一位 52 岁男性因滤泡性淋巴瘤而出现腭扁桃体肿胀。他的肿瘤负担较低，但观察到打鼾和吞咽困难加重。考虑到第一波 2019 年冠状病毒病（COVID-19）大流行，他接受了 4Gy 的姑息性双剂量扁桃体照射，这导致扁桃体肿胀部分消退和循环淋巴瘤细胞消除。我们建议低剂量放疗引发了淋巴瘤的远隔效应，使患者有时间在开始免疫抑制化疗免疫治疗之前接种 COVID-19 疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d57e/9646336/a7460cfde98c/1349-7235-61-3107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d57e/9646336/5fe7f3a70607/1349-7235-61-3107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d57e/9646336/ac97948c9563/1349-7235-61-3107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d57e/9646336/a7460cfde98c/1349-7235-61-3107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d57e/9646336/5fe7f3a70607/1349-7235-61-3107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d57e/9646336/ac97948c9563/1349-7235-61-3107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d57e/9646336/a7460cfde98c/1349-7235-61-3107-g003.jpg

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Efficacy of low-dose radiotherapy (2 Gy × 2) in the treatment of marginal zone and mucosa-associated lymphoid tissue lymphomas.低剂量放疗（2 Gy×2）治疗边缘区和黏膜相关淋巴组织淋巴瘤的疗效
Br J Radiol. 2021 Jul 1;94(1123):20210012. doi: 10.1259/bjr.20210012. Epub 2021 Jun 16.
3
4 Gy versus 24 Gy radiotherapy for follicular and marginal zone lymphoma (FoRT): long-term follow-up of a multicentre, randomised, phase 3, non-inferiority trial.
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Poor outcome and prolonged persistence of SARS-CoV-2 RNA in COVID-19 patients with haematological malignancies; King's College Hospital experience.血液系统恶性肿瘤的COVID-19患者中SARS-CoV-2 RNA的不良预后和长期持续存在；国王学院医院的经验。
Br J Haematol. 2020 Sep;190(5):e279-e282. doi: 10.1111/bjh.16935. Epub 2020 Aug 10.
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